8-Hydroxy-2'-Deoxyguanosine as an Oxidative Stress Marker in Insomnia.

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ID: 268978
2021
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Abstract
We performed comparative analysis of 8-hydroxy-2'-deoxyguanosine in women in different climax stages with and without insomnia. The study involved 90 women aged 45 to 60 years divided into perimenopausal (n=30) and postmenopausal (n=60) groups. After questioning using special sleep questionnaires (Insomnia Severity Index, Epworth Sleepiness Scale, Munich Chronotype Questionnaire), the groups were divided into subgroups with insomnia and without it (control). 8-Hydroxy-2'-deoxyguanosine was assayed in blood serum by ELISA. The higher levels of 8-hydroxy-2'-deoxyguanosine in postmenopausal women with insomnia in comparison with the control and perimenopausal patients (p<0.05) attested to oxidative DNA damage in this cohort of patients.
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Authors Semenova, N V;Madaeva, I M;Brichagina, A S;Kolesnikov, S I;Kolesnikova, L I;
Journal Bulletin of experimental biology and medicine
Year 2021
DOI
10.1007/s10517-021-05233-0
URL
Keywords
oxidative stress insomnia 8-hydroxy-2’-deoxyguanosine perimenopause postmenopause

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