Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis
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2000
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Abstract
The DMP1 transcription factor induces the ARF tumor suppressor gene in mouse fibroblasts, leading to cell cycle arrest in a p53-dependent manner. We disrupted sequences encoding the DNA-binding domain of DMP1 in mouse embryonic stem cells and derived ...
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| Reference Key |
sherr2000genesdisruption
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| Authors | Kazushi Inoue, Renren Wen, Jerold E. Rehg, Masashi Adachi, John L. Cleveland, Martine F. Roussel, Charles J. Sherr;Kazushi Inoue;Renren Wen;Jerold E. Rehg;Masashi Adachi;John L. Cleveland;Martine F. Roussel;Charles J. Sherr; |
| Journal | genes & development |
| Year | 2000 |
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