The Sodium Channel of Human Excitable Cells is a Target for Gambierol

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ID: 268881
2006
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Abstract
Gambierol is a polycyclic ether toxin with the same biogenetic origin as ciguatoxins. Gambierol has been associated with neurological symptoms in humans even though its mechanism of action has not been fully characterized. We studied the effect of gambierol in human neuroblastoma cells by using bis-oxonol to measure membrane potential and FURA-2 to monitor intracellular calcium. We found that this toxin: i) produced a membrane depolarization, ii) potentiated the effect of veratridine on membrane potential iii) decreased ciguatoxin-induced depolarization and iv) increased cytosolic calcium in neuroblastoma cells. These results indicate that gambierol modulate ion fluxes by acting as a partial agonist of sodium channels.
Reference Key
botana2006cellularthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors M. Carmen Louzao,Eva Cagide,Mercedes Rodriguez Vieytes,Makoto Sasaki,Haruhiko Fuwa,Takeshi Yasumoto,Luis M. Botana;M. Carmen Louzao;Eva Cagide;Mercedes Rodriguez Vieytes;Makoto Sasaki;Haruhiko Fuwa;Takeshi Yasumoto;Luis M. Botana;
Journal cellular physiology and biochemistry
Year 2006
DOI
10.1159/000094138
URL
https://sciprofiles.com/publication/view/7d3ac43c2ced902068abe454fdab2a07
Keywords
ciguatoxins sodium channel human excitable polycyclic ether gambierol gambierol biogenetic origin

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