The Sodium Channel of Human Excitable Cells is a Target for Gambierol
Clicks: 166
ID: 268881
2006
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
7.8
/100
26 views
26 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Gambierol is a polycyclic ether toxin with the same biogenetic origin as ciguatoxins. Gambierol has been associated with neurological symptoms in humans even though its mechanism of action has not been fully characterized. We studied the effect of gambierol in human neuroblastoma cells by using bis-oxonol to measure membrane potential and FURA-2 to monitor intracellular calcium. We found that this toxin: i) produced a membrane depolarization, ii) potentiated the effect of veratridine on membrane potential iii) decreased ciguatoxin-induced depolarization and iv) increased cytosolic calcium in neuroblastoma cells. These results indicate that gambierol modulate ion fluxes by acting as a partial agonist of sodium channels.
| Reference Key |
botana2006cellularthe
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | M. Carmen Louzao,Eva Cagide,Mercedes Rodriguez Vieytes,Makoto Sasaki,Haruhiko Fuwa,Takeshi Yasumoto,Luis M. Botana;M. Carmen Louzao;Eva Cagide;Mercedes Rodriguez Vieytes;Makoto Sasaki;Haruhiko Fuwa;Takeshi Yasumoto;Luis M. Botana; |
| Journal | cellular physiology and biochemistry |
| Year | 2006 |
| DOI |
10.1159/000094138
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.