Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage

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ID: 268767
1994
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Abstract
Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We studied the involvement of these loci in 13 large HNPCC kindreds originating from three different continen …
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Authors Nyström-Lahti M, Parsons R, Sistonen P, Pylkkänen L, Aaltonen LA, Leach FS, Hamilton SR, Watson P, Bronson E, Fusaro R
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Journal American journal of human genetics
Year 1994
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/7942843
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't adult female male middle aged P.H.S. DNA human Genetic Markers mutation chromosome mapping chromosomes pedigree genetic linkage pmid:7942843 pmc1918295 m nyström-lahti r parsons r fusaro pair 2* pair 3* colorectal neoplasms hereditary nonpolyposis / blood hereditary nonpolyposis / genetics* dna repair / genetics* satellite / blood satellite / isolation & purification lod score MSH2 linkage families repair mismatch mlh1 locus kindreds

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