Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

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ID: 268701
2001
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Abstract
Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age. Retention and expression of the wild-type Dmp1 allele in tumors arising in Dmp1(+/-) mice demonstrate that Dmp1 can be haplo-insufficient for tu …
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Authors Inoue K;Zindy F;Randle DH;Rehg JE;Sherr CJ;;
Journal genes & development
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11711428
Keywords
experimental National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't age factors P.H.S. DNA Genes Immunoblotting Genotype time factors in situ hybridization messenger / metabolism transcription factors / genetics* disease-free survival transcription factors / physiology* signal transduction neoplasms mutation* reverse transcriptase polymerase chain reaction neoplasm metastasis transcriptional activation cyclin-dependent kinase inhibitor p16 / genetics gene deletion proto-oncogene proteins c-myc / genetics* alleles complementary / metabolism rna / metabolism F Zindy pmid:11711428 pmc312824 doi:10.1101/gad.929901 k inoue c j sherr p53 / genetics* lymphoma / chemically induced lymphoma / genetics tumor suppressor protein p14arf / genetics*

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