SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

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ID: 268646
1994
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Abstract
Sterol regulatory element-binding protein 1 (SREBP-1), a member of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors, is synthesized as a 125 kd precursor that is attached to the nuclear envelope and endoplasmic reticulum. In sterol-depleted cells, the membrane-bou …
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Authors Wang X;Sato R;Brown MS;Hua X;Goldstein JL;;
Journal Cell
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8156598
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't amino acid sequence P.H.S. x wang DNA-Binding Proteins / metabolism* Nuclear Proteins / metabolism* Transcription Factors / metabolism* Molecular Sequence Data hela cells molecular weight cell nucleus / metabolism sterol regulatory element binding protein 1 j l goldstein sterols / pharmacology* nuclear proteins / chemistry ccaat-enhancer-binding proteins* dna-binding proteins / chemistry pmid:8156598 doi:10.1016/0092-8674(94)90234-8 r sato cell compartmentation / drug effects intracellular membranes / metabolism membrane lipids / metabolism membrane proteins / chemistry membrane proteins / metabolism protein precursors / metabolism

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