Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis

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ID: 268562
2008
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Abstract
The fibroblast growth factor (FGF) regulates a broad spectrum of biological activities by activation of transmembrane FGF receptor (FGFR) tyrosine kinases and their coupled intracellular signaling pathways. FGF receptor substrate 2alpha (FRS2alpha) is an FGFR interactive adaptor protein that links m …
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Authors Zhang Y;Zhang J;Lin Y;Lan Y;Lin C;Xuan JW;Shen MM;McKeehan WL;Greenberg NM;Wang F;;
Journal development (cambridge, england)
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18184727
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. male N.I.H. Extramural epithelium / pathology sexual maturation / drug effects enzyme activation / drug effects epithelium / metabolism cell proliferation / drug effects organ specificity / drug effects membrane proteins / genetics androgens / pharmacology alleles epithelial cells / pathology prostatic neoplasms / pathology* prostatic neoplasms / metabolism* mitogen-activated protein kinases / metabolism epithelial cells / drug effects epithelial cells / metabolism* pmid:18184727 doi:10.1242/dev.009910 yongyou zhang jue zhang fen wang epithelial cells / enzymology developmental / drug effects membrane proteins / metabolism* organogenesis* prostate / drug effects prostate / enzymology prostate / growth & development* prostate / pathology regeneration* / drug effects

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