The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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1970
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Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leuk …
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Authors Adams JM;Harris AW;Pinkert CA;Corcoran LM;Alexander WS;Cory S;Palmiter RD;Brinster RL;;
Journal Nature
Year 1970
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/3906410
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. DNA Genes enhancer elements genetic* recombination transcription cell differentiation proto-oncogene proteins / genetics* recombinant oncogenes* pmid:3906410 doi:10.1038/318533a0 j m adams a w harris r l brinster b-lymphocytes / pathology regulator* immunoglobulins / genetics* lymphoma / genetics*

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