Biological Activity of 4-Acetyltropolone, the Minor Component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAK.

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ID: 268478
2002
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Abstract
4-Acetyltropolone, a minor component of Thujopsis dolabrata SIEB. et ZUCC. hondai MAKINO, showed antimicrobial activity against various microorganisms including wood-rotting fungi, a phytogrowth-inhibitory effect with chlorophyll biosynthesis inhibition, cytotoxic effect and inhibitory activity on metalloproteases. This compound had strong antifungal activity on Daedalea dickinsii IFO-4979 [minimum inhibitory concentration (MIC): 0.2 μg/ml] and Coriolus versicolor IFO-4940 (MIC: 0.39 μg/ml). Its cytotoxic effect at 20.0 μg/ml on human stomach cancer KATO-III and Ehrich's ascites carcinoma was stronger than those of podophyllotoxin, vincristine and vinblastine, the anticancer agents isolated from higher plants and used clinically. This compound also had potent antibacterial activity against Staphylococcus epidermidis IFO-12993, its MIC being 1.56 μg/ml. However, other biological activities of 4-acetyltropolone were lower than those of hinokitiol which is the main component of this plant, suggesting that the contribution of the acetyl group at C-4 to biological activity is smaller than that of the isopropyl group at that position. The acute toxicity of 4-acetyltropolone (LD50: 335.2 mg/kg) to mice was much lower than that of hinokitiol (LD50: 191 mg/kg).
Reference Key
inamori2002biologicalbiological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yasuhiro Morita,Eiko Matsumura,Hiroshi Tsujibo,Masahide Yasuda,Toshihiro Okabe,Yoshikazu Sakagami,Yuko Kumeda,Nakao Ishida,Yoshihiko Inamori;Yasuhiro Morita;Eiko Matsumura;Hiroshi Tsujibo;Masahide Yasuda;Toshihiro Okabe;Yoshikazu Sakagami;Yuko Kumeda;Nakao Ishida;Yoshihiko Inamori;
Journal biological and pharmaceutical bulletin
Year 2002
DOI
10.1248/bpb.25.981
URL
https://sciprofiles.com/publication/view/16faf989b756bb4d4e4952b27027b02e
Keywords
cytotoxic microorganisms wood zucc hondai thujopsis acetyltropolone ld50 dolabrata sieb hinokitiol

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