Transient prenatal androgen exposure produces metabolic syndrome in adult female rats

Clicks: 326
ID: 268256
2008
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Abstract
Androgen exposure during intrauterine life in nonhuman primates and in sheep results in a phenocopy of the reproductive and metabolic features of polycystic ovary syndrome (PCOS). Such exposure also results in reproductive features of PCOS in rodents. We investigated whether transient prenatal andro …
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Authors Demissie M;Lazic M;Foecking EM;Aird F;Dunaif A;Levine JE;;
Journal American journal of physiology. Endocrinology and metabolism
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18544644
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine pregnancy research support female N.I.H. Extramural Rats Sprague-Dawley liver / metabolism testosterone / pharmacology* polycystic ovary syndrome / metabolism body weight / drug effects glucose tolerance test insulin resistance / physiology* signal transduction insulin / blood triglycerides / blood prenatal exposure delayed effects muscle skeletal / metabolism adipose tissue / drug effects metabolic syndrome / metabolism* cholesterol / blood pmid:18544644 pmc2519755 doi:10.1152/ajpendo.90208.2008 marek demissie milos lazic jon e levine dietary fats / metabolism

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