Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat

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ID: 268099
1995
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Abstract
Mutations in the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in severely compromised immune system. To identify the causative gene, we utilized modern tools and techniques of positional cloning. Specifically, spanning the region in which the n …
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Authors Segre JA;Nemhauser JL;Taylor BA;Nadeau JH;Lander ES;;
Journal genomics
Year 1995
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/7490093
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't female male amino acid sequence P.H.S. Rats DNA Base Sequence Molecular Sequence Data mutation Crosses DNA-Binding Proteins / genetics* transcription transcription factors / genetics* nude chromosome mapping e s lander pmid:7490093 doi:10.1006/geno.1995.1187 j a segre j l nemhauser complementary / analysis forkhead transcription factors inbred akr restriction mapping

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