Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Clicks: 215
ID: 268097
1998
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Abstract
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19[ARF] tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression ...
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| Reference Key |
roussel1998genesmyc
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|---|---|
| Authors | Frederique Zindy, Christine M. Eischen, David H. Randle, Takehiko Kamijo, John L. Cleveland, Charles J. Sherr, Martine F. Roussel;Frederique Zindy;Christine M. Eischen;David H. Randle;Takehiko Kamijo;John L. Cleveland;Charles J. Sherr;Martine F. Roussel; |
| Journal | genes & development |
| Year | 1998 |
| DOI |
10.1101/gad.12.15.2424
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| URL | |
| Keywords |
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