17β-estradiol inhibits hepatic iNOS via the activation of the estrogen receptor ER-α and inhibition of erk1/2-mir-221 axis

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1970
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Abstract
17β-Estradiol (E2) is known to negatively regulate inducible nitric oxide (NO) synthase (iNOS) expression via estrogen receptor alpha (ER-α) activation in aortic vascular smooth muscle cells.Therefore, we sought to determine whether E2 can inhibit iNOS in vivo in hepatic tissue via the activa …
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Authors Panic A;Stanimirovic J;Obradovic M;Zafirovic S;Sudar-Milovanovic E;Petrovic N;Isenovic ER;;
Journal journal of biological regulators and homeostatic agents
Year 1970
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