Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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ID: 268001
2002
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Abstract
According to the hitherto accepted view, neutrophils kill ingested microorganisms by subjecting them to high concentrations of highly toxic reactive oxygen species (ROS) and bringing about myeloperoxidase-catalysed halogenation. We show here that this simple scheme, which for many years has served a …
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Authors Reeves EP;Lu H;Jacobs HL;Messina CG;Bolsover S;Gabella G;Potma EO;Warley A;Roes J;Segal AW;;
Journal Nature
Year 2002
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11907569
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't superoxides / metabolism candidiasis / immunology immunologic* cytotoxicity neutrophils / immunology* staphylococcal infections / immunology electrophysiology enzyme activation pmid:11907569 doi:10.1038/416291a emer p reeves hui lu anthony w segal oxygen / metabolism peroxidase / deficiency peroxidase / metabolism* phagosomes / physiology potassium / metabolism*

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