Function and biological roles of the Dickkopf family of Wnt modulators - Oncogene

Clicks: 219
ID: 267953
2006
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Star

Ranked #60 of 239 articles by views in Oncogene

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 239 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted proteins that typically antagonize Wnt/β-catenin signaling, by inhibiting the Wnt coreceptors Lrp5 and 6. Additionally, Dkks are high affinity ligands for the transmembrane proteins Kremen1 and 2, which also modulate Wnt signaling. Dkks play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero–posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
Reference Key
niehrs2006oncogenefunction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C Niehrs;C Niehrs;
Journal Oncogene
Year 2006
DOI
doi:10.1038/sj.onc.1210054
URL
https://doi.org/10.1038%2Fsj.onc.1210054
Keywords
cell biology oncology apoptosis internal medicine general medicine/public health human genetics

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.