Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Clicks: 300
ID: 267949
1998
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Abstract
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression in primary MEFs and triggers replicative …
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Authors Zindy F;Eischen CM;Randle DH;Kamijo T;Cleveland JL;Sherr CJ;Roussel MF;;
Journal genes & development
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9694806##mesh-terms
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression animals humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't P.H.S. cell line Genes mutation biological proteins / genetics* apoptosis / genetics* signal transduction gene deletion pmid:9694806 PMC317045 doi:10.1101/gad.12.15.2424 F Zindy C M Eischen M F Roussel Cell Division / genetics Tumor Suppressor myc* p53* Tumor Suppressor Protein p14ARF

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