Methotrexate influx via folate transporters into alveolar epithelial cell line A549

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ID: 267936
2015
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Abstract
Methotrexate (MTX), a drug used for the treatment of certain cancers as well as rheumatoid arthritis, sometimes induces serious interstitial lung injury. Although lung toxicity of MTX is related to its accumulation, the information concerning MTX transport in the lungs is lacking. In this study, we …
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m2015drugmethotrexate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kawami M;Miyamoto M;Yumoto R;Takano M;;
Journal drug metabolism and pharmacokinetics
Year 2015
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/26190800
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line Biological Transport / drug effects kinetics hydrogen-ion concentration pmid:26190800 doi:10.1016/j.dmpk.2015.04.005 masashi kawami mioka miyamoto mikihisa takano biological transport / physiology carrier proteins / metabolism epithelial cells / drug effects epithelial cells / metabolism* folic acid / metabolism* folic acid transporters / metabolism* methotrexate / metabolism* proton-coupled folate transporter / metabolism pulmonary alveoli / drug effects pulmonary alveoli / metabolism* sulfasalazine / pharmacology

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