Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator

Clicks: 289
ID: 267792
1997
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Abstract
The nuclear factor kappaB (NF-kappaB) transcription factor is responsive to specific cytokines and stress and is often activated in association with cell damage and growth arrest in eukaryotes. NF-kappaB is a heterodimeric protein, typically composed of 50- and 65-kilodalton subunits of the Rel fami …
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Authors Perkins ND;Felzien LK;Betts JC;Leung K;Beach DH;Nabel GJ;;
Journal Science (New York, N.Y.)
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8999795
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. cell line Genes Nuclear Proteins / metabolism* Transcription Factors / metabolism* cell cycle signal transduction transfection transcription factors / genetics nf-kappa b / metabolism* phosphorylation reporter nuclear proteins / genetics protein-serine-threonine kinases / metabolism* tetradecanoylphorbol acetate / pharmacology trans-activators* protein-serine-threonine kinases / genetics pmid:8999795 doi:10.1126/science.275.5299.523 n d perkins l k felzien g j nabel cdc2-cdc28 kinases* cyclin-dependent kinase 2 cyclin-dependent kinase inhibitor p21 cyclin-dependent kinases / genetics cyclin-dependent kinases / metabolism* cyclins / genetics cyclins / metabolism jurkat cells nf-kappa b / genetics protein kinases / metabolism transcription factor rela transcriptional activation*

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