Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes

Clicks: 366
ID: 267754
2006
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Abstract
Our results indicate that chloroquine-mediated inhibition of TNF-alpha, IL-1beta and IL-6 synthesis occurs through different modes in lipopolysaccharide-stimulated human monocytes/macrophages: it blocks the conversion of cell-associated TNF-alpha precursor to mature soluble protein, whereas it reduc …
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ch2006rheumatologychloroquine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jang CH;Choi JH;Byun MS;Jue DM;;
Journal rheumatology (oxford, england)
Year 2006
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16418198
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Cells Cultured Messenger / genetics gene expression regulation / drug effects dose-response relationship drug antirheumatic agents / pharmacology* tumor cells macrophages / drug effects cytokines / genetics lipopolysaccharides / immunology cytokines / biosynthesis* macrophages / immunology interleukin-1 / biosynthesis tumor necrosis factor-alpha / biosynthesis tumor necrosis factor-alpha / genetics pmid:16418198 doi:10.1093/rheumatology/kei282 c-h jang j-h choi d-m jue chloroquine / pharmacology* interleukin-1 / genetics interleukin-6 / biosynthesis interleukin-6 / genetics monocytes / drug effects* monocytes / immunology reverse transcriptase polymerase chain reaction / methods

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