Twist is a potential oncogene that inhibits apoptosis

Clicks: 308
ID: 267574
1999
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Abstract
Oncogene activation increases susceptibility to apoptosis. Thus, tumorigenesis must depend, in part, on compensating mutations that protect from programmed cell death. A functional screen for cDNAs that could counteract the proapoptotic effects of the myc oncogene identified two related bHLH family …
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Authors Maestro R;Dei Tos AP;Hamamori Y;Krasnokutsky S;Sartorelli V;Kedes L;Doglioni C;Beach DH;Hannon GJ;;
Journal genes & development
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10485844
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. P.H.S. Rats cell line Genes Transcription Factors / metabolism* transcription factors / genetics cell transformation neoplastic cell division p53 gene deletion fibroblasts apoptosis* ras nuclear proteins* pmid:10485844 pmc317004 doi:10.1101/gad.13.17.2207 r maestro a p dei tos g j hannon myc helix-loop-helix motifs oncogenes* repressor proteins* rhabdomyosarcoma / genetics tumor suppressor protein p53 / metabolism twist-related protein 1

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