Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2

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2000
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Abstract
Toll-like receptor (TLR) 2 has recently been associated with cellular responses to numerous microbial products, including LPS and bacterial lipoproteins. However, many preparations of LPS contain low concentrations of highly bioactive contaminants described previously as "endotoxin protein," suggest …
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Authors Hirschfeld M;Ma Y;Weis JH;Vogel SN;Weis JJ;;
Journal Journal of immunology (Baltimore, Md. : 1950)
Year 2000
DOI
DOI not found
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http://www.ncbi.nlm.nih.gov/pubmed/10878331
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Cells Cultured cell line Receptors gene expression regulation / drug effects signal transduction / drug effects transfection tumor cells lipopolysaccharides / pharmacology signal transduction / immunology* inbred c3h phenol drosophila proteins* membrane glycoproteins / genetics cell surface / genetics toll-like receptor 4 toll-like receptors pmid:10878331 doi:10.4049/jimmunol.165.2.618 m hirschfeld y ma j j weis drug contamination gene expression regulation / immunology genetic vectors / genetics genetic vectors / immunology lipid a / isolation & purification lipid a / pharmacology lipopolysaccharides / isolation & purification* membrane glycoproteins / biosynthesis membrane glycoproteins / physiology* cell surface / biosynthesis cell surface / physiology* toll-like receptor 2

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