Elevated Level of Wnt5a Protein in Localized Prostate Cancer Tissue Is Associated with Better Outcome

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ID: 267555
2011
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Abstract
Background Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays an important role in cancer development and progression. Previous studies report that Wnt5a is upregulated in prostate cancer and suggested that Wnt5a affects migration and invasion of prostate tumor cell. This study aimed to evaluate the prognostic value of Wnt5a protein expression in prostate cancer tissue and its potential to predict outcome after radical prostatectomy in patients with localized prostate cancer. Methodology and Results Immunohistochemical analysis of a tissue microarray containing prostate specimens of 503 patients with localized prostate cancer showed significantly higher Wnt5a protein expression in cancer compared to benign cores from the same patients (p
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Authors Azharuddin Sajid Syed Khaja;Leszek Helczynski;Anders Edsjö;Roy Ehrnström;Anna Lindgren;David Ulmert;Tommy Andersson;Anders Bjartell;
Journal PloS one
Year 2011
DOI
10.1371/journal.pone.0026539
URL
https://doi.org/10.1371%2Fjournal.pone.0026539
Keywords
Breast cancer prostate cancer protein expression prostate gland cell staining du145 cells immunostaining nuclear staining

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