Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex

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2013
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Abstract
Norrin is a cysteine-rich growth factor that is required for angiogenesis in the eye, ear, brain, and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding to the Frizzled 4 (Fz4) receptor. Here we report the crystal ...
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xu2013genesstructure Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jiyuan Ke, Kaleeckal G. Harikumar, Clara Erice, Chen Chen, Xin Gu, Liren Wang, Naomi Parker, Zhihong Cheng, Wenqing Xu, Bart O. Williams, Karsten Melcher, Laurence J. Miller, H. Eric Xu;Jiyuan Ke;Kaleeckal G. Harikumar;Clara Erice;Chen Chen;Xin Gu;Liren Wang;Naomi Parker;Zhihong Cheng;Wenqing Xu;Bart O. Williams;Karsten Melcher;Laurence J. Miller;H. Eric Xu;
Journal genes & development
Year 2013
DOI
10.1101/gad.228544.113
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828517/
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