Histoplasma capsulatum utilizes siderophores for intracellular iron acquisition in macrophages

Clicks: 285
ID: 267356
2011
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Abstract
Histoplasma capsulatum is a dimorphic fungal pathogen that survives and replicates within macrophages (MΦ). Studies in human and murine MΦ demonstrate that the intracellular growth of H. capsulatum yeasts is exquisitely sensitive to the availability of iron. As H. capsulatum produces hydroxamate sid …
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Authors Hilty J;George Smulian A;Newman SL;;
Journal medical mycology
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21341981
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support male N.I.H. Extramural Disease Models Animal Cells Cultured lung diseases / pathology Survival Analysis microbial lung / microbiology macrophages / microbiology* iron / metabolism* colony count gene knockout techniques pmid:21341981 doi:10.3109/13693786.2011.558930 jeremy hilty a george smulian simon l newman gene knockdown techniques histoplasma / metabolism* histoplasma / pathogenicity* histoplasmosis / microbiology histoplasmosis / pathology lung diseases / microbiology rodent diseases / microbiology rodent diseases / pathology siderophores / genetics siderophores / metabolism* spleen / microbiology

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