Age-Related Loss of Cohesion: Causes and Effects

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ID: 267187
2017
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Abstract
Aneuploidy is a leading genetic cause of birth defects and lower implantation rates in humans. Most errors in chromosome number originate from oocytes. Aneuploidy in oocytes increases with advanced maternal age. Recent studies support the hypothesis that cohesion deterioration with advanced maternal age represents a leading cause of age-related aneuploidy. Cohesin generates cohesion, and is established only during the premeiotic S phase of fetal development without any replenishment throughout a female’s period of fertility. Cohesion holds sister chromatids together until meiosis resumes at puberty, and then chromosome segregation requires the release of sister chromatid cohesion from chromosome arms and centromeres at anaphase I and anaphase II, respectively. The time of cohesion cleavage plays an important role in correct chromosome segregation. This review focuses specifically on the causes and effects of age-related cohesion deterioration in female meiosis.
Reference Key
cheng2017internationalage-related Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jin-Mei Cheng;Yi-Xun Liu;Cheng, Jin-Mei;Liu, Yi-Xun;
Journal International journal of molecular sciences
Year 2017
DOI
10.3390/ijms18071578
URL
https://www.mdpi.com/1422-0067/18/7/1578##related_content
Keywords
age aneuploidy oocytes cohesion National Center for Biotechnology Information NCBI NLM MEDLINE review animals humans pubmed abstract nih national institutes of health national library of medicine female male chromosomes human* / genetics anaphase / genetics* pmid:28737671 pmc5536066 doi:10.3390/ijms18071578 jin-mei cheng yi-xun liu aging* / genetics aging* / metabolism aging* / pathology aneuploidy* chromatids* / genetics chromatids* / metabolism chromosome segregation / genetics* human* / metabolism oocytes / pathology

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