Association of the APC gene product with beta-catenin

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ID: 267097
1993
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Abstract
Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton …
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Authors Rubinfeld B;Souza B;Albert I;Müller O;Chamberlain SH;Masiarz FR;Munemitsu S;Polakis P;;
Journal Science (New York, N.Y.)
Year 1993
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8259518
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence Antibodies Cultured cell line Genes Molecular Sequence Data cell adhesion tumor cells colonic neoplasms / genetics precipitin tests colonic neoplasms / metabolism* trans-activators* beta catenin cytoskeletal proteins / metabolism* pmid:8259518 doi:10.1126/science.8259518 b rubinfeld b souza p polakis adenomatous polyposis coli protein cadherins / metabolism* cytoskeletal proteins / chemistry cytoskeletal proteins / isolation & purification apc* neoplasm proteins / genetics neoplasm proteins / immunology neoplasm proteins / metabolism*

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