PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations

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ID: 267053
2018
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Abstract
Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel–Trenaunay syndrome. ...
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Authors Laura di Blasio, Alberto Puliafito, Paolo Armando Gagliardi, Valentina Comunanza, Desiana Somale, Giulia Chiaverina, Federico Bussolino, Luca Primo;Laura di Blasio;Alberto Puliafito;Paolo Armando Gagliardi;Valentina Comunanza;Desiana Somale;Giulia Chiaverina;Federico Bussolino;Luca Primo;
Journal Cell death & disease
Year 2018
DOI
10.1038/s41419-017-0064-x
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833448
Keywords
cell biology biochemistry cell culture immunology life sciences antibodies general

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