Exposure-efficacy Relationships for Vedolizumab Induction Therapy in Patients with Ulcerative Colitis or Crohn's Disease

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ID: 266889
2017
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Abstract
Higher vedolizumab serum concentrations were associated with higher remission rates after induction therapy in patients with moderately to severely active UC or CD. This relationship is affected by several factors, including previous TNFα antagonist use. Prospective studies are needed to assess vedo …
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Authors Rosario M;French JL;Dirks NL;Sankoh S;Parikh A;Yang H;Danese S;Colombel JF;Smyth M;Sandborn WJ;Feagan BG;Reinisch W;Sands BE;Sans M;Fox I;;
Journal journal of crohn's & colitis
Year 2017
DOI
DOI not found
URL
https://www.pubmed.gov/28333288/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome adult female male adolescent aged middle aged young adult 80 and over Randomized Controlled Trial Antibodies Monoclonal Double-Blind Method Humanized / therapeutic use* Colitis Ulcerative / drug therapy* Gastrointestinal Agents / therapeutic use* dose-response relationship drug crohn disease / drug therapy* remission induction / methods feces / chemistry serum albumin / analysis pmid:28333288 doi:10.1093/ecco-jcc/jjx021 maria rosario jonathan l french irving fox humanized / administration & dosage humanized / blood gastrointestinal agents / administration & dosage leukocyte l1 antigen complex / analysis

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