Towards Lateral Flow Quantitative Assays: Detection Approaches

Clicks: 212
ID: 266843
2019
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Abstract
Point-of-care (POC) or bedside analysis is a global trend in modern diagnostics. Progress in POC testing has largely been provided by advanced manufacturing technology for lateral flow (immunochromatographic) test strips. They are widely used to rapidly and easily control a variety of biomarkers of infectious diseases and metabolic and functional disorders, as well as in consumer protection and environmental monitoring. However, traditional lateral flow tests rely on visual assessment and qualitative conclusion, which limit the objectivity and information output of the assays. Therefore, there is a need for approaches that retain the advantages of lateral flow assays and provide reliable quantitative information about the content of a target compound in a sample mixture. This review describes the main options for detecting, processing, and interpreting immunochromatographic analysis results. The possibilities of modern portable detectors that register colored, fluorescent, magnetic, and conductive labels are discussed. Prospects for further development in this direction are also examined.
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urusov2019biosensorstowards Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alexandr E. Urusov;Anatoly V. Zherdev;Boris B. Dzantiev;Urusov, Alexandr E.;Zherdev, Anatoly V.;Dzantiev, Boris B.;
Journal Biosensors
Year 2019
DOI
10.3390/bios9030089
URL
https://www.mdpi.com/2079-6374/9/3/89
Keywords
immunochromatography rapid tests immunoassay portable detectors optical detection

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