BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

Clicks: 344
ID: 266773
2004
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
In humans, mutations in BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden disease, respectively. The development of polyposis is a common feature of these diseases, suggesting that there is an association between BMP and PTEN pathways. T …
Reference Key
xc2004naturebmp Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors He XC;Zhang J;Tong WG;Tawfik O;Ross J;Scoville DH;Tian Q;Zeng X;He X;Wiedemann LM;Mishina Y;Li L;;
Journal nature genetics
Year 2004
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/15378062
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Disease Models Animal Receptors transgenic stem cells / cytology signal transduction pmid:15378062 doi:10.1038/ng1430 xi c he jiwang zhang linheng li adenomatous polyposis coli / etiology adenomatous polyposis coli / genetics bone morphogenetic protein receptors type i bone morphogenetic proteins / physiology* cytoskeletal proteins / physiology* epithelial cells / pathology intestines / cytology* mutant strains pten phosphohydrolase protein tyrosine phosphatases / physiology protein-serine-threonine kinases / genetics protein-serine-threonine kinases / physiology proto-oncogene proteins / physiology* proto-oncogene proteins c-akt growth factor / genetics growth factor / physiology trans-activators / physiology* tumor suppressor proteins / physiology wnt proteins beta catenin

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.