Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein

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ID: 266704
1996
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Abstract
Repair of a uracil-guanine base pair in DNA has been reconstituted with the recombinant human proteins uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta and DNA ligase III. The XRCC1 protein, which is known to bind DNA ligase III, is not absolutely required for the reac …
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y1996thereconstitution Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, Lindahl T
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Journal the embo journal
Year 1996
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/8978692
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't DNA-Binding Proteins / metabolism* Base Sequence blotting western dna-binding proteins / isolation & purification substrate specificity cell-free system base composition recombinant proteins / metabolism pmid:8978692 pmc452490 y kubota r a nash t lindahl dna glycosylases* dna polymerase i / isolation & purification dna polymerase i / metabolism* dna repair* dna-(apurinic or apyrimidinic site) lyase deoxyribonuclease iv (phage t4-induced) guanine lyases / metabolism n-glycosyl hydrolases / metabolism* recombinant proteins / isolation & purification uracil uracil-dna glycosidase x-ray repair cross complementing protein 1

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