Transcription factor-specific requirements for coactivators and their acetyltransferase functions

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ID: 266556
1998
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Abstract
Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)-functionally require distinct components of the coactivator complex, including CREB- …
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Authors Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG
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Journal Science (New York, N.Y.)
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9445475
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. P.H.S. genetic* Nuclear Proteins / metabolism* Receptors Transcription Factors / metabolism* mutation ligands Promoter Regions transcription hela cells transcription factors / genetics cell cycle proteins / genetics cell cycle proteins / metabolism* transcriptional activation dna-binding proteins / metabolism creb-binding protein histone acetyltransferases nuclear receptor coactivator 1 saccharomyces cerevisiae proteins* trans-activators / metabolism stat1 transcription factor pmid:9445475 doi:10.1126/science.279.5351.703 e korzus j torchia m g rosenfeld acetyltransferases / genetics acetyltransferases / metabolism* cyclic amp / metabolism cyclic amp response element-binding protein / metabolism nuclear receptor co-repressor 1 nuclear receptor coactivator 3 retinoic acid / metabolism repressor proteins / metabolism p300-cbp transcription factors

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