Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

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ID: 266515
1994
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Abstract
CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by blocking access of sequence-specific activator proteins (activators) to their promoter-binding sites. For example, the DNA-binding domain of the yeast GAL4 protein interacts very poorly with nucleosome core …
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Authors Kwon H;Imbalzano AN;Khavari PA;Kingston RE;Green MR;;
Journal Nature
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8047169
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't P.H.S. DNA-Binding Proteins / metabolism* Transcription Factors / metabolism* recombinant proteins hela cells protein conformation protein binding dna / metabolism saccharomyces cerevisiae / genetics adenosine triphosphate / metabolism adenosine triphosphatases saccharomyces cerevisiae proteins* pmid:8047169 doi:10.1038/370477a0 h kwon a n imbalzano m r green dna helicases fungal proteins / metabolism nuclear proteins* nucleosomes / chemistry nucleosomes / metabolism* trans-activators / metabolism xenopus

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