Different Region Analysis for Genotyping Yersinia pestis Isolates from China

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ID: 266392
2008
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Abstract
BackgroundDFR (different region) analysis has been developed for typing Yesinia pestis in our previous study, and in this study, we extended this method by using 23 DFRs to investigate 909 Chinese Y. pestis strains for validating DFR-based genotyping method and better understanding adaptive microevolution of Y. pestis.Methodology/Principal FindingsOn the basis of PCR and Bionumerics data analysis, 909 Y. pestis strains were genotyped into 32 genomovars according to their DFR profiles. New terms, Major genomovar and Minor genomovar, were coined for illustrating evolutionary relationship between Y. pestis strains from different plague foci and different hosts. In silico DFR profiling of the completed or draft genomes shed lights on the evolutionary scenario of Y. pestis from Y. pseudotuberculosis. Notably, several sequenced Y. pestis strains share the same DFR profiles with Chinese strains, providing data for revealing the global plague foci expansion.Conclusions/significanceDistribution of Y. pestis genomovars is plague focus-specific. Microevolution of biovar Orientalis was deduced according to DFR profiles. DFR analysis turns to be an efficient and inexpensive method to portrait the genome plasticity of Y. pestis based on horizontal gene transfer (HGT). DFR analysis can also be used as a tool in comparative and evolutionary genomic research for other bacteria with similar genome plasticity.
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Authors Yanjun Li;Erhei Dai;Yujun Cui;Min Li;Yujiang Zhang;Mingshou Wu;Dongsheng Zhou;Zhaobiao Guo;Xiang Dai;Baizhong Cui;Zhizhen Qi;Zuyun Wang;Hu Wang;Xingqi Dong;Zhizhong Song;Junhui Zhai;Yajun Song;Ruifu Yang;
Journal PloS one
Year 2008
DOI
10.1371/journal.pone.0002166
URL
https://doi.org/10.1371/journal.pone.0002166
Keywords
genomics genotyping genome analysis yersinia pestis plagues microevolution bacterial genomics yersinia pseudotuberculosis

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