DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
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ID: 266157
2017
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Abstract
PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria.
| Reference Key |
boldinova2017internationaldna
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| Authors | Elizaveta O. Boldinova;Paulina H. Wanrooij;Evgeniy S. Shilkin;Sjoerd Wanrooij;Alena V. Makarova;Boldinova, Elizaveta O.;Wanrooij, Paulina H.;Shilkin, Evgeniy S.;Wanrooij, Sjoerd;Makarova, Alena V.; |
| Journal | International journal of molecular sciences |
| Year | 2017 |
| DOI |
10.3390/ijms18071584
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| URL | |
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