A signature motif in transcriptional co-activators mediates binding to nuclear receptors

Clicks: 365
ID: 266056
1997
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Abstract
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA-binding and transcriptional properties of these receptors, resulting in the activation or repression of target genes. Ligand binding induces conformational changes in nuclear re …
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Authors Heery DM;Kalkhoven E;Hoare S;Parker MG;;
Journal Nature
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9192902
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence conserved sequence genetic* Nuclear Proteins / metabolism* Receptors Cytoplasmic and Nuclear / metabolism* Transcription Factors / metabolism* ligands transcription transfection nuclear proteins / genetics protein structure dna / metabolism recombinant fusion proteins / metabolism secondary adaptor proteins signal transducing pmid:9192902 doi:10.1038/42750 d m heery e kalkhoven m g parker creb-binding protein histone acetyltransferases nuclear proteins / chemistry nuclear receptor coactivator 1 nuclear receptor coactivator 2 nuclear receptor interacting protein 1 cytoplasmic and nuclear / chemistry estrogen / chemistry estrogen / metabolism recombinant fusion proteins / chemistry trans-activators* transcription factors / chemistry

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