Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1

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ID: 265994
1988
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Abstract
A 42-base pair sequence from the 5' flanking region of the low density lipoprotein receptor gene was shown previously to confer sensitivity to sterol-mediated repression when inserted into the herpes simplex virus thymidine kinase promoter. This sequence contains two contiguous 16-base pair repeats, …
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Authors Dawson PA;Hofmann SL;van der Westhuyzen DR;Südhof TC;Brown MS;Goldstein JL;;
Journal The Journal of biological chemistry
Year 1988
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/3277969
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. cell line DNA genetic* plasmids DNA-Binding Proteins / metabolism* Receptors Transcription Factors / metabolism* Base Sequence mutation Promoter Regions Messenger / genetics transcription gene expression regulation / drug effects* nucleic acid cricetinae repetitive sequences transfection binding sites base composition pmid:3277969 p a dawson s l hofmann j l goldstein recombinant ldl / genetics* sp1 transcription factor sterols / pharmacology* thymidine kinase / genetics

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