High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model

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ID: 265981
2009
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Abstract
Interleukin (IL)-15, is a cytokine that is important for the maintenance of long-lasting, high-avidity T cell response to invading pathogens and has, therefore, been used in vaccine and therapeutic platforms as an adjuvant. In addition to pure protein delivery, plasmids encoding the IL-15 gene have …
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j2009virologyhigh Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yin J, Dai A, Laddy DJ, Yan J, Arango T, Khan AS, Lewis MG, Andersen H, Kutzler MA, Draghia-Akli R, Weiner DB, Boyer JD
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Journal Virology
Year 2009
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19683780
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural Antibodies plasmids viral / blood vaccines dose-response relationship drug macaca mulatta hemagglutination inhibition tests cd8-positive t-lymphocytes / immunology cell proliferation cd4-positive t-lymphocytes / immunology intramural pmid:19683780 pmc4118595 doi:10.1016/j.virol.2009.07.017 jiangmei yin anlan dai jean d boyer influenza vaccines / genetics influenza vaccines / immunology* interferon-gamma / metabolism interleukin-15 / genetics interleukin-15 / immunology* dna / genetics dna / immunology*

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