Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

Clicks: 266
ID: 265940
1998
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Abstract
The promoter selectivity factor Sp1 often cooperates with other enhancer-binding proteins to activate transcription. To study the molecular underpinnings of these regulatory events, we have reconstituted in vitro the synergy observed in vivo between Sp1 ...
Reference Key
tjian1998geneschromatin, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anders M. Näär, Pierre A. Beaurang, Karen M. Robinson, Jon D. Oliner, Daina Avizonis, Sigrid Scheek, Jörk Zwicker, James T. Kadonaga, Robert Tjian;Anders M. Näär;Pierre A. Beaurang;Karen M. Robinson;Jon D. Oliner;Daina Avizonis;Sigrid Scheek;Jörk Zwicker;James T. Kadonaga;Robert Tjian;
Journal genes & development
Year 1998
DOI
10.1101/gad.12.19.3020
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC317191/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Drosophila animals humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't P.H.S. Receptors DNA-Binding Proteins / physiology* Nuclear Proteins / physiology* Promoter Regions hela cells drug synergism transcription factors* sterol regulatory element binding protein 1 chromatin / physiology* ccaat-enhancer-binding proteins* LDL / genetics r tjian transcription factor tfiid transcriptional activation* pmid:9765204 pmc317191 doi:10.1101/gad.12.19.3020 a m näär p a beaurang helix-loop-helix motifs / physiology* leucine zippers / physiology* sp1 transcription factor / physiology* transcription factors tfii / physiology

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