ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs
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2020
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Abstract
Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular ...
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manley2020genesals/ftd-associated
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| Authors | Yueh-Lin Tsai, Tristan H. Coady, Lei Lu, Dinghai Zheng, Isabel Alland, Bin Tian, Neil A. Shneider, James L. Manley;Yueh-Lin Tsai;Tristan H. Coady;Lei Lu;Dinghai Zheng;Isabel Alland;Bin Tian;Neil A. Shneider;James L. Manley; |
| Journal | genes & development |
| Year | 2020 |
| DOI |
10.1101/gad.335836.119
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