The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

Clicks: 291
ID: 265758
2015
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Abstract
Pancreatic beta cell death is a hallmark of type 1 (T1D) and type 2 (T2D) diabetes, but the molecular mechanisms underlying this aspect of diabetic pathology are poorly understood. Here we report that expression of the microRNA (miR)-200 family is strongly induced in islets of diabetic mice and that …
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Authors Belgardt BF;Ahmed K;Spranger M;Latreille M;Denzler R;Kondratiuk N;von Meyenn F;Villena FN;Herrmanns K;Bosco D;Kerr-Conte J;Pattou F;Rülicke T;Stoffel M;;
Journal Nature Medicine
Year 2015
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/25985365
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't diabetes mellitus signal transduction apoptosis / genetics insulin / metabolism inbred nod micrornas / metabolism pmid:25985365 doi:10.1038/nm.3862 bengt-frederik belgardt kashan ahmed markus stoffel cell survival / genetics type 2 / genetics* type 2 / pathology hsp40 heat-shock proteins / biosynthesis insulin-secreting cells / metabolism* insulin-secreting cells / pathology micrornas / genetics* x-linked inhibitor of apoptosis protein / biosynthesis

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