Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat

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2012
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Abstract
Treatment with TGF-β2 prevents mucosal-injury, enhances p-ERK and β-catenin induced enterocyte proliferation, inhibits enterocyte apoptosis and improves intestinal recovery following MTX-induced intestinal-mucositis in rats.
Reference Key
s2012plosdietary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ben-Lulu S, Pollak Y, Mogilner J, Bejar J, G Coran A, Sukhotnik I
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Journal PloS one
Year 2012
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/22984629
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male dietary supplements Apoptosis / drug effects Rats Sprague-Dawley Receptors body weight / drug effects recombinant proteins / pharmacology blotting western cell survival / drug effects recombinant proteins / administration & dosage reverse transcriptase polymerase chain reaction intestinal mucosa / pathology intestinal mucosa / metabolism beta catenin / metabolism pmid:22984629 pmc3440324 doi:10.1371/journal.pone.0045221 shani ben-lulu yulia pollak igor sukhotnik antimetabolites antineoplastic / toxicity caco-2 cells enterocytes / drug effects enterocytes / metabolism enterocytes / pathology interleukin-1beta / metabolism intestinal mucosa / drug effects* methotrexate / toxicity* mucositis / chemically induced mucositis / metabolism mucositis / prevention & control* proto-oncogene proteins c-bcl-2 / genetics transforming growth factor beta / metabolism transforming growth factor beta2 / administration & dosage transforming growth factor beta2 / genetics transforming growth factor beta2 / pharmacology* bcl-2-associated x protein / genetics bcl-2-associated x protein / metabolism

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