Electro-Mechanical Whole-Heart Digital Twins: A Fully Coupled Multi-Physics Approach

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ID: 265656
2021
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Abstract
Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful tool to understand the mechanisms underlying pathophysiological conditions. In this study, we present a detailed mathematical description of a fully coupled multi-scale model of the human heart, including electrophysiology, mechanics, and a closed-loop model of circulation. State-of-the-art models based on human physiology are used to describe membrane kinetics, excitation-contraction coupling and active tension generation in the atria and the ventricles. Furthermore, we highlight ways to adapt this framework to patient specific measurements to build digital twins. The validity of the model is demonstrated through simulations on a personalized whole heart geometry based on magnetic resonance imaging data of a healthy volunteer. Additionally, the fully coupled model was employed to evaluate the effects of a typical atrial ablation scar on the cardiovascular system. With this work, we provide an adaptable multi-scale model that allows a comprehensive personalization from ion channels to the organ level enabling digital twin modeling.
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gerach2021mathematicselectro-mechanical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tobias Gerach;Steffen Schuler;Jonathan Fröhlich;Laura Lindner;Ekaterina Kovacheva;Robin Moss;Eike Moritz Wülfers;Gunnar Seemann;Christian Wieners;Axel Loewe;Gerach, Tobias;Schuler, Steffen;Fröhlich, Jonathan;Lindner, Laura;Kovacheva, Ekaterina;Moss, Robin;Wülfers, Eike Moritz;Seemann, Gunnar;Wieners, Christian;Loewe, Axel;
Journal Mathematics
Year 2021
DOI
10.3390/math9111247
URL
https://doi.org/10.3390/math9111247
Keywords
computational modeling whole heart electro-mechanic coupling multi-physics closed-loop circulation

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