Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

العلاج المتأخر بمضاد الفيروسات بالإضافة إلى مُعدِّل المناعة لا يزال يقلل من معدل الوفيات لدى الفئران المصابة بجرعة تلقيح عالية من فيروس الإنفلونزا A/H5N1

Clicks: 634
ID: 265610
2008
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #4 of 292 articles by views in Proceedings of the National Academy of Sciences of the United States of America

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 292 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The mortality of human infection by influenza A/H5N1 virus can exceed 80%. The high mortality and its poor response to the neuraminidase inhibitor oseltamivir have been attributed to uncontrolled virus-induced cytokine storm. We challenged BALB/c mice with 1,000 LD50 of influenza A/Vietnam/1194/04. …
يمكن أن يتجاوز معدل الوفيات الناجمة عن إصابة البشر بفيروس الإنفلونزا A/H5N1 نسبة 80%. وقد عُزي ارتفاع معدل الوفيات وضعف الاستجابة لمثبط النيورامينيداز أوسيلتاميفير إلى عاصفة السيتوكين غير المنضبطة والمستحثة بالفيروس. قمنا بإخضاع فئران BALB/c للتحدي بـ 1,000 LD50 من فيروس الإنفلونزا A/Vietnam/1194/04. …
Reference Key
bj2008proceedingsdelayed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zheng BJ, Chan KW, Lin YP, Zhao GY, Chan C, Zhang HJ, Chen HL, Wong SS, Lau SK, Woo PC, Chan KH, Jin DY, Yuen KY
Are you one of these authors? Claim your profile
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18523003
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Inbred BALB C Survival Analysis lung / pathology time factors survival rate antiviral agents / therapeutic use* body weight / drug effects viral load antiviral agents / pharmacology influenza a virus lung / virology lymphocyte count kwok-yung yuen t-lymphocytes / drug effects pmid:18523003 pmc2430364 doi:10.1073/pnas.0711942105 bo-jian zheng kwok-wah chan albumins / metabolism chemokines / metabolism immunologic factors / pharmacology immunologic factors / therapeutic use* h5n1 subtype / drug effects h5n1 subtype / physiology* lung / drug effects orthomyxoviridae infections / drug therapy* prostaglandins / metabolism t-lymphocytes / virology

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.