Synthesis and Spectroscopic Identification Of A New Series Of Biologically Active 2-Iminothiazolidine-4-One Derivatives

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ID: 265389
2014
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Abstract
A series of 2-amino-5-(substituted phenyl) 1,3,4- thiadiazol have been synthesized through the reaction of  thiosemicarbazide with substituted  benzoic acids in the presence of phosphoroxy chloride readily undergo  nucleophilic addition – elimination reaction with chloroacetyl chloride in benzene as a solvent to afford 2-chloro acetamido compounds. The prepared compounds were subjected  cyclization reaction and results in the formation of a series of 2- imino-3-(substituted phenyl)  1,3,4- thiadiazol-2yl-thiazolidinone -4 one .  The IR ,1H and 13C- NMR spectra of the prepared compounds were confirmed to their proposed structures . Finally antimicrobial activity of the newly obtained compounds were tested against Klepsilla pneumonia (gram -ve )     and  Staphylococcusaurous (gram + ve)  and the results showed that most of the prepared compounds are sensitive against both types of test organisms in different activities .
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azeez2014synthesisscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Azeez, Hashim J.;Abdulla, Venos S.;
Journal science journal of university of zakho
Year 2014
DOI
DOI not found
URL
https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/136
Keywords
Organic Chemistry Science

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