Invasive aspergillosis in patients with hematological malignancies in the Czech and Slovak republics: Fungal InfectioN Database (FIND) analysis, 2005-2009.

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ID: 265284
2013
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Abstract
To evaluate risk factors, diagnostic procedures, and treatment outcomes of invasive aspergillosis (IA) in patients with hematological malignancies.A retrospective analysis of data from proven/probable IA cases that occurred from 2005 to 2009 at 10 hematology centers was performed.We identified 176 IA cases that mainly occurred in patients with acute leukemias (58.5%), mostly those on induction/re-induction treatments (39.8%). Prolonged neutropenia was the most frequent risk factor for IA (61.4%). The lungs were the most frequently affected site (93.8%) and computed tomography detected abnormalities in all episodes; however, only 53.7% of patients had findings suggestive of IA. Galactomannan (GM) detection in serum or bronchoalveolar lavage fluid (positive in 79.1% and 78.8% of episodes, respectively) played a crucial role in IA diagnosis. Neutrophil count and antifungal prophylaxis did not influence the GM positivity rate, but empirical therapy decreased this rate (in serum). Of the IA cases, 53.2% responded to initial antifungal therapy. The combination of voriconazole and echinocandin, even as initial or salvage therapy, did not perform better than voriconazole monotherapy (p=0.924 for initial therapy and p=0.205 for salvage therapy). Neutrophil recovery had a significant role in the response to initial (but not salvage) antifungal therapy.Our retrospective analysis identified key diagnostic and treatment characteristics, and this understanding could improve the management of hematological malignancy patients with IA.
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racil2013invasiveinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Racil, Zdenek;Weinbergerova, Barbora;Kocmanova, Iva;Muzik, Jan;Kouba, Michal;Drgona, Lubos;Masarova, Lucia;Guman, Tomas;Tothova, Elena;Forsterova, Kristina;Haber, Jan;Ziakova, Barbora;Bojtarova, Eva;Vydra, Jan;Mudry, Peter;Foralova, Renata;Sejnova, Daniela;Mallatova, Nada;Kandrnal, Vit;Cetkovsky, Petr;Mayer, Jiri;
Journal International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Year 2013
DOI
10.1016/j.ijid.2012.09.004
URL
Keywords
Screening ultrasound birth weight gestational age fetal growth

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