Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report.

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ID: 265276
2019
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Abstract
Galectins belong to the family of galactose-binding proteins known to play an important role in the processes of cell proliferation, differentiation, migration and neoplastic progression. Herein, we studied the expression of galectin-3 (Gal-3) in chronic lymphocytic leukemia (CLL).The expression of Gal-3 was analyzed by means of multiparametric flow cytometry in normal and pathological B-cells from peripheral blood and bone marrow samples of 67 patients with CLL.Pathological B-cells expressed significantly higher levels of cytoplasmic Gal-3 than normal B-cells. Moreover, overexpression of cytoplasmic Gal-3 was observed in the prognostically poorest subgroup of CLL patients, namely those with 17p deletion.Our results indicate a possible role of galectin-3 in CLL pathophysiology and its potential value as a prognostic marker and therapeutic target.
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michalov2019overexpressionanticancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michalová, Zuzana;Čoma, Matúš;Kičová, Miroslava;Gabzdilová, Juliana;Dedinská, Kinga;Guman, Tomáš;Hájiková, Martina;Veselinyová, Dominika;Giertlova, Mária;Gál, Peter;Šarišský, Marek;
Journal Anticancer research
Year 2019
DOI
10.21873/anticanres.13408
URL
Keywords
flow cytometry cytogenetics chronic lymphocytic leukemia galectin-3 17p deletion b-cells

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