Recent Insights into Clostridium perfringens Beta-Toxin

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ID: 265120
2015
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Abstract
Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect. Experimental investigation using piglet and rabbit intestinal loop models and a mouse infection model apparently showed that beta-toxin is the important pathogenic factor of the organisms. The toxin caused the swelling and disruption of HL-60 cells and formed a functional pore in the lipid raft microdomains of sensitive cells. These findings represent significant progress in the characterization of the toxin with knowledge on its biological features, mechanism of action and structure-function having been accumulated. Our aims here are to review the current progresses in our comprehension of the virulence of C. perfringens type C and the character, biological feature and structure-function of beta-toxin.
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nagahama2015recenttoxins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nagahama, Masahiro;Ochi, Sadayuki;Oda, Masataka;Miyamoto, Kazuaki;Takehara, Masaya;Kobayashi, Keiko;
Journal Toxins
Year 2015
DOI
DOI not found
URL
http://www.mdpi.com/2072-6651/7/2/396
Keywords
Microbiology Veterinary medicine Medicine Science animal culture

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