Identification of PGC-1α activating constituents in Zingiberaceous crude drugs.

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ID: 264481
2017
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Abstract
The activity of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) as an index of thermogenesis induced by four Indonesian Zingiberaceous crude drugs, Boesenbergia rotunda, Curcuma longa, Kaempferia galanga, Zingiber montanum, was examined, and GC-MS analyses of extracts of these drugs were performed. The results showed that activation of PGC-1α by K. galanga was high, whereas no activation was shown for the other drugs. Ethyl p-methoxycinnamate and ethyl cinnamate were identified as the PGC-1α activating compounds of K. galanga. Furthermore, study on the structure-activity relationship revealed that ethyl p-methoxycinnamate has the strongest activity among the cinnamic acid derivatives. This suggests that the ester structure and the methoxy group are important factors responsible for the PGC-1α activity.
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nishidono2017identificationfitoterapia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nishidono, Yuto;Fujita, Takashi;Kawanami, Akira;Nishizawa, Mikio;Tanaka, Ken;
Journal Fitoterapia
Year 2017
DOI
S0367-326X(17)31006-7
URL
Keywords
zingiberaceae pgc-1α ethyl p-methoxycinnamate kaempferia galanga

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