New Biflavonoids with α-Glucosidase and Pancreatic Lipase Inhibitory Activities from Boesenbergia rotunda.

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2017
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Abstract
Roots of (L.) Mansf. are prominent ingredients in the cuisine of several Asian countries, including Thailand, Malaysia, Indonesia, India, and China. An extract prepared from the roots of this plant showed strong inhibitory activity against enzymes α-glucosidase and pancreatic lipase and was subjected to chromatographic separation to identify the active components. Three new biflavonoids of the flavanone-chalcone type (, , and ) were isolated, along with 12 known compounds. Among the 15 isolates, the three new compounds showed stronger inhibitory activity against α-glucosidase than the drug acarbose but displayed lower pancreatic lipase inhibitory effect than the drug orlistat. The results indicated the potential of roots as a functional food for controlling after-meal blood glucose levels.
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chatsumpun2017newmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chatsumpun, Nutputsorn;Sritularak, Boonchoo;Likhitwitayawuid, Kittisak;
Journal molecules
Year 2017
DOI
E1862
URL
Keywords
α-glucosidase boesenbergia rotunda biflavonoid cyclohexenyl chalcone flavanone-chalcone pancreatic lipase

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